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ORIGINAL ARTICLE
Year : 2013  |  Volume : 3  |  Issue : 1  |  Page : 53-57

Clinico-laboratory profile of severe Plasmodium vivax malaria in a tertiary care centre in Kolkata


1 Department of Medicine, North Bengal Medical College, Darjeeling, India
2 Department of Medicine, Calcutta National Medical College and Hospital, Kolkata, India
3 Department of Medicine, Medical College and Hospital, Kolkata, India
4 Department of Medicine, Malda Medical College and Hospital, Malda, India

Correspondence Address:
Sayantan Ray
Department of Medicine, Calcutta National Medical College and Hospital, Kolkata - 700 014, West Bengal
India
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DOI: 10.4103/2229-5070.113912

PMID: 23961442

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Background: Vivax malaria is the most widely distributed human malaria and is responsible for up to 400 million infections every year. Recently, it has become evident that Plasmodium vivax monoinfection could also result in multiple organ dysfunction and severe life-threatening disease as seen in Plasmodium falciparum infection. Materials and Methods: The aim of this study was to note the different clinical and biochemical profiles of adult patients with the severe vivax malaria with regards to complications and outcome. This was a prospective observational study carried out at a tertiary care hospital in Kolkata over 9 month's period. Detailed history and examination findings were noted in all patients. Their clinical presentations, complications, course in ward until discharge or death was noted. Results: A total of 900 cases of vivax malaria were included in the study. Severe disease was present in 200 (22.2%) cases of malaria. There were 108 (54%) patients with single complication (SC) and 92 (46%) patients with the multiple complications (MC). Patients with SC had jaundice (48.1%) followed by cerebral involvement (25.9%), renal failure (7.4%), and pulmonary involvement (3.7%). The MC was found in various combinations and the majority (47.8%) had constellation of two different complications. The mortality rate of patients with the SC and MC was 7.4% and 34.8%. The overall mortality observed in severe vivax malaria was 20% (40/200). Conclusions: In recent years, the clinical pattern of vivax malaria has changed. Severe vivax malaria is now very common with increasing mortality. Not only the number, but also the type of complication influences the outcome of complicated malaria.


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