Trichomonas vaginalis and Mycoplasma infections among women with vaginal discharge at Fann teaching hospital in Senegal
Roger C Tine1, Lamine Dia2, Khadime Sylla1, Doudou Sow1, Souleye Lelo3, Cheikh T Ndour4
1 Department of Medical Parasitology, Faculty of Medicine, University Cheikh Anta Diop; Centre for Diagnostic and Medical Imagery, Laboratory of Parasitology and Mycology, Fann Teaching Hospital, Dakar, Senegal
2 Centre for Diagnostic and Medical Imagery, Laboratory of Bacteriology and Virology, Fann Teaching Hospital, Dakar, Senegal
3 Centre for Diagnostic and Medical Imagery, Laboratory of Parasitology and Mycology, Fann Teaching Hospital, Dakar, Senegal
4 Department of Infectious and Tropical Diseases, Fann Teaching Hospital, Dakar; Division for AIDS and Sexually Transmitted Infections Control, Ministry of Health, Senegal
Roger C Tine
Department of Medical Parasitology, Faculty of Medicine, University Cheikh Anta Diop, BP: 5005 Dakar, Fann, Dakar
Background: Trichomonas vaginalis and genital Mycoplasmas are two synergistic pathogens, but in many settings, limited data on the co-infection by Trichomonas and Mycoplasma are available.
Objective: This study aimed at assessing Mycoplasma prevalence and its association with Trichomonas vaginalis among women with vaginal discharge.
Materials and Methods: A retrospective analysis of laboratory records (2012 and 2013) from patients referred at the Fann teaching hospital in Dakar Senegal for vaginal discharge was carried out. Detection of genital mycoplasmas was based on the commercial Kit Mycoplasma Duo Bio-Rad™ using endo-cervical swabs. Vaginal swabs were collected and examined using optic microscopy with 40x magnification to detect T. vaginalis.
Results: Overall, data from 1257 women were analysed. Prevalence of Mycoplasma hominis represented 57.4%, 95%CI(54.6-60.1), versus 54.9%, 95%CI(52.1-57.5) for Ureaplasma urealyticum. Trichomonas vaginalis infection was observed with a frequency of 3%. Out of the 50 patients with trichomoniasis, 76% of them were co-infected by Mycoplasma hominis and patients with Trichomonas vaginalis had an increased risk of acquiring Mycoplasma infection (adjusted OR:2.5, 95%CI(1.2-5.2);p=0.02)).
Conclusion: Trichomonas vaginalis and Mycoplasmas are two closely associated pathogens in the urogenital tract of women. This clinically significant symbiotic action may require systematic screening of Mycoplasma among patients with trichomoniasis for optimal management of sexually transmitted infections.