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Helminths and multiple sclerosis: The light at the end of the tunnel

 Department of Medical Parasitology, Assiut University, Egypt

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   Abstract 

Multiple sclerosis (MS) incidence has significantly increased recently, generating considerable interest in analyzing the basis for this rise in the developed world. Particular emphasis is being placed on the role infections might play in exacerbating or preventing disease onset. Given that helminth infections are thought to have strong immunomodulatory activity, particular interest is being focused on the workings of the mammalian immune response to helminth parasites, with the hope of revealing molecules and/or mechanisms that can be translated into developing new approach. This approach should involve increasing good regulating cells in the body instead of focusing on stopping "bad" or "effector" cells. Indeed, the story began with allergic disorders, followed by inflammatory bowel diseases, but now MS is increasingly involved. Here, the various epidemiological, experimental, clinical, and molecular data supporting the protective role of helminthes against MS is highlighted and exemplified.

Keywords: Helminths, hygiene, hypothesis, immunomodulation, multiple sclerosis


How to cite this URL:
Huseein EA. Helminths and multiple sclerosis: The light at the end of the tunnel. Trop Parasitol [Epub ahead of print] [cited 2017 Nov 23]. Available from: http://www.tropicalparasitology.org/preprintarticle.asp?id=145580


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Correspondence Address:
Enas AM Huseein,
Department of Medical Parasitology, Assiut University
Egypt
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Source of Support: None, Conflict of Interest: None





 

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