Tropical Parasitology

REVIEW ARTICLE
Year
: 2018  |  Volume : 8  |  Issue : 2  |  Page : 70--76

Drug susceptibility testing methods of antimalarial agents


Ardhendu K Maji 
 Department of Microbiology, Calcutta School of Tropical Medicine, Kolkata, West Bengal, India

Correspondence Address:
Dr Ardhendu K Maji
Department of Microbiology, Calcutta School of Tropical Medicine, 108, C. R. Avenue, Kolkata - 700 073, West Bengal
India

Resistance to almost all available antimalarial agents, particularly for Plasmodium falciparum, is an important issue throughout all malaria endemic countries. Recently, Plasmodium vivax also showed resistance to chloroquine in some part of the World. Monitoring efficacy of used antimalarial drugs plays an important role to determine the emergence of resistant power by the prevailing parasite population of a geographical area if any. There are four different methods for antimalarial drug efficacy study. In vivo therapeutic efficacy study remains the gold standard and provides primary data for formulating antimalarial drug policy by the National Malaria Control Programmes. Several in vitro assay methods for assessing antimalarial drug susceptibility have been developed during past few decades. These assay methods are simple, easier to handle and allow early detection of drug-resistant parasites and also for the screening of different newly developed agents for their antimalarial activity. Approaches of different assay methods for testing the susceptibility of antimalarial agents and their limitations are discussed in this review article.


How to cite this article:
Maji AK. Drug susceptibility testing methods of antimalarial agents.Trop Parasitol 2018;8:70-76


How to cite this URL:
Maji AK. Drug susceptibility testing methods of antimalarial agents. Trop Parasitol [serial online] 2018 [cited 2019 Mar 19 ];8:70-76
Available from: http://www.tropicalparasitology.org/article.asp?issn=2229-5070;year=2018;volume=8;issue=2;spage=70;epage=76;aulast=Maji;type=0