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 Table of Contents  
CASE REPORT
Year : 2011  |  Volume : 1  |  Issue : 2  |  Page : 116-118  

Ocular filariasis


1 Department of Microbiology, HI-TECH Medical College and Hospital, Bhubaneswar, Odisha, India
2 Department of Microbiology, S.C.B Medical College and Hospital, Cuttack, Odisha, India
3 Department of Ophthalmology, S.C.B Medical College and Hospital, Cuttack, Odisha, India

Date of Web Publication31-Oct-2011

Correspondence Address:
Bibhudutta Rautaraya
C/o Harish Chandra Rautaraya, M.B-24,1st Floor, Baragada BRIT Colony, Bhubaneswar-751 018, Odisha
India
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DOI: 10.4103/2229-5070.86957

PMID: 23508719

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   Abstract 

Human ocular infestation by a live filarial adult worm is a rare occurrence. We report a case of ocular infestation of a female adult Brugia malayi. A 35-year-old female presented with chief complaint of severe headache, blurring of vision, redness, and lacrimation since one year. On examination, there was conjunctival chemosis, congestion, and white-colored worm with wriggling movement in the anterior chamber of eye. The worm removed by paracentesis of anterior chamber. Identification basing on typical morphology showed to be adult female B.malayi, and was confirmed by immunochromatographic test. The patient responded completely to diethylcarbamazine treatment. Live adult worm in the anterior chamber of eye is uncommon in India; nevertheless, ophthalmologists should be aware of this clinical manifestation and go for a proper identification of the worm.

Keywords: Anterior chamber filariasis, Brugia malayi, ocular infestation


How to cite this article:
Rautaraya B, Tiwari S, Mahapatra A, Nanda A. Ocular filariasis. Trop Parasitol 2011;1:116-8

How to cite this URL:
Rautaraya B, Tiwari S, Mahapatra A, Nanda A. Ocular filariasis. Trop Parasitol [serial online] 2011 [cited 2020 Oct 25];1:116-8. Available from: https://www.tropicalparasitology.org/text.asp?2011/1/2/116/86957


   Introduction Top


Intraocular infestation by the filarial worm is a rare occurrence in humans and most of the published reports are from Southeast Asia. [1] Lymphatic filariasis caused by Brugia malayi occurs in southwest India, China, Indonesia, Malaysia, Korea, Philippines, and Vietnam. [2] Brugian filariasis is mainly a rural disease and transmitted by mosquitoes of the genera Mansonia, Anopheles, and Aedes. Domestic animals like cats and dogs may serve as reservoirs of infection. During a blood meal, mosquitoes ingest microfilaria and they become infective in 10 days. Patients contract the disease through repeated episodes of mosquito bite.

The ocular manifestations of filariasis are elephantiasis of the eyelids, iritis, retinal hemorrhages, or the presence of microfilaria in the lacrimal gland secretion. [3] Entry into the anterior chamber may be through ciliary vessels.

Here we report a case of a woman belonging to slum area of Kendarapara distritict of Odisha. In this patient, live adult worm was found wriggling in the anterior chamber of the left eye.


   Case Report Top


A 35-year-old female belonging to the slum area of kendarapara district of Odisha presented to the ophthalmology outpatient department with chief complaint of severe headache, blurring of vision, redness, and lacrimation since one year in left eye. The right eye was normal. The symptoms were insidious in onset and progressive in nature. The patient was a housewife and had some pet animals like cats and dogs. On examination, conjunctival chemosis, congestion, lacrimation, and white-colored worm with wriggling movement in the anterior chamber of left eye [Figure 1]. Movement of the live worm was seen during slit lamp examination of the left eye. The conjunctival fornices and the cornea were normal. Ocular movement and fudoscopy of both the eyes were normal. The worm removed by paracentesis of the anterior chamber and was sent in normal saline to the department of microbiology. Under low and high power magnification, morphology of the parasite studied in wet mount as well as after staining with leishman stain. The worm was found to be approximately 40 mm in length, and 130 μm in breadth.[Figure 2]. In the leishman-stained smear, the worm had a blunt cephalic end with slight bulging [Figure 3]. There was no clear demarcation of the mouthparts anteriorly. The tail end slightly curved and tapered. There was long double-walled tube with a normal lumen, which merged with the uterus [Figure 4]. The posterior end showed many cuticular bossing. Due to the above-mentioned typical features, the worm identified to be adult B.malayi. Immunochromatographic test (ICT) for filarial (Wuchereria bancrofti) antigen was negative. The sensitivity and specificity of ICT for filarial antigen is 96 to 100% and 95 to 100%, respectively.
Figure 1: White-colored worm in the anterior chamber of eye

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Figure 2: Coiled adult worm (200×)

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Figure 3: Distended mouth part (400×)

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Figure 4: Long doubled-walled tube merging with the uterus (400×)

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   Discussion Top


The first recorded case of B.malayi microfilaria in a patient with uveitis was reported by Anandakanan and Gupta in 1977 in India. [4] Rose (1960) reported an unproven case of B.malayi adult worm in the anterior chamber of the eye of a man in Malaysia. [5] Mak et al (1974) report a case of human eye infection caused by adult worm of B.malayi in Malaysia. [6] Rao et al reported intravitreal live adult Brugian filarisis from Orissa. [1]

B.malayi is a helminth belonging to class nematodes. Man is the definitive host for B.malayi, the intermediate host being species of Mansonian mosquito. Adult worms live in the lymphatic system discharging live embryo (microfilariae) into the blood stream, which are capable of living in the peripheral blood for a considerable period without undergoing any developmental metamorphosis. Intermediate host takes up microfilariae where they undergo further development becoming infective to man.

The most common clinical presentation of ocular filarial infestation is chemosis, lid edema, orbital cellulitis anterior uveitis, or worm in the anterior chamber.

Once a parasite is identified in the vitreous cavity it should be removed immediately live and intact. Immediate removal is necessary because (i) it is capable of migrating to various parts of the eye and could cause structural damage and severe intraocular reaction, (ii) severed parasite may cause serious intraocular inflammation, and (iii) intact parasite is necessary for proper identification of species and any systemic treatment if needed for it. [7],[8]

The drug of choice for lymphatic filariasis is diethylcarbamazine (DEC). This regimen clears microfilariae from the blood and has a limited but definite effect on adult parasites. Use of ivermectin, in trials for therapy for lymphatic filariasis, in a single dose, appears to be as effective as DEC at clearing microfilariae. [9] Karam and Ottesen in 2000 reported that combined treatment using albendazole plus ivermectin or albendazole plus diethylcarbamazine

has resulted in near-zero microfilaremia levels for at least one year. Based on these new developments, the World Health Assembly adopted a resolution calling on member states to work for the elimination of lymphatic filariasis as a public health problem. [10]

One of the control measures is mosquito eradication. Mansonia species are the major vectors in rural areas. Control of mansonia mosquitoes is by destruction or removal of the aquatic vegetation.

 
   References Top

1.Rao NG, Mahapatra SK, Pattnayak S, Pattnaik K. Intraviteral live adult Brugian filariasis. Indian J Ophthalmol 2008;56:76-8.  Back to cited text no. 1
[PUBMED]  Medknow Journal  
2.Tsieh S. Bancroftian filariasis and Brugian filariasis. Color atlas and textbook of diagnostic parasitology. New York: Igaku-Shoin; 1988. p 195-9.  Back to cited text no. 2
    
3.Toussaint D, Danis P. Retinopathy in generalized loa-loa filariasis. A clinicopathological study. Arch Ophthalmol 1965;74:470-6.  Back to cited text no. 3
[PUBMED]  [FULLTEXT]  
4.Anandakannan K, Gupta CP. Microfilaria malayi in uveitis: Case report. Br J Ophthalmol 1977;61:263-4.  Back to cited text no. 4
[PUBMED]  [FULLTEXT]  
5.Rose L. Filarial worm in anterior chamber of eye in man. Arch Ophthalmol 1966;75:13-5.  Back to cited text no. 5
[PUBMED]  [FULLTEXT]  
6.Mak JW, Singh D, Sukoaryono J, Sivanandam S. Brugia malayi infection of the human eye: A case report. Southeast Asian J Trop Med Public Health 1974;5:226-9.  Back to cited text no. 6
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7.Biswas J, Gopal L, Sharma T, Badrinath SS. Intraocular Gnathostoma spinigerum. Clinico-pathological study of two cases with review of Literature. Retina 1994;14:438-44.  Back to cited text no. 7
[PUBMED]    
8.Basak SK, Sinha TK, Debasis B, Tushar KH, Parikh S. Intravitreal live Gnathostoma spinigerum. Indian J Ophthalmol 2004;52:57-8.   Back to cited text no. 8
[PUBMED]  Medknow Journal  
9.Nutman TB, Weller PE. Filariasis and related infections (loiasis, onchocerciasis, and dracunculiasis). Harrison's principles of internal medicine. International edition, 14 th ed, vol. 1. USA: McGraw-Hill; 1998. p. 1212.  Back to cited text no. 9
    
10.Karam M, Ottesen E. The control of lymphatic filariasis. Med Trop (Mars) 2000;60:291-6.  Back to cited text no. 10
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    Figures

  [Figure 1], [Figure 2], [Figure 3], [Figure 4]


This article has been cited by
1 Live Brugia malayi in the anterior chamber: a case report from India
A Mohan,A Verghese,M Raman,J Biswas
Eye. 2014;
[Pubmed] | [DOI]



 

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