| ORIGINAL ARTICLE |
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| Year : 2020 | Volume
: 10
| Issue : 1 | Page : 29-33 |
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Endothelial dysfunction in acute acquired toxoplasmosis
Azhar H Al-Kuraishi, Salah D Al-Windy, Hayder M Al-Kuraishy, Ali I Al-Gareeb
Department of Pharmacology, Toxicology and Medicine, College of Medicine Almustansiriya University, Baghdad, Iraq
Correspondence Address:
Hayder M Al-Kuraishy
Department of Pharmacology, Toxicology and Medicine, College of Medicine Almustansiriya University, P. O. Box 14132 Baghdad
Iraq
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DOI: 10.4103/tp.TP_26_19 
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Background: Acute toxoplasmosis (AT) which is caused by Toxoplasma gondii (T. gondii) leads to induction of pro-inflammatory and/or oxidative stress changes through activation of host immune response. Therefore, the endeavor of the present study was to assess endothelial dysfunction(ED) and oxidative stress in patients with acute toxoplasmosis.
Methods: This study involved 21 patients with AT compared with 20 healthy controls. Serum immunoglobulin levels [IgG], IgM, IgA), Interleukin-6 (IL-6), endothelin-1 (ET-1), and human malondialdehyde (MDA) serum levels were evaluated.
Results: IgM, IgG, and IgA levels were high patients with AT as compared with the control (P < 0.01). IL-6, MDA, and ET-1 serum levels were high in patients with AT compared with control (P < 0.01). In patients with AT, IgM serum level was significantly correlated with other immunoglobulin, and with the biomarker of oxidative stress, lipid peroxidation, and ED (P = 0.0001).
Conclusion: AT is linked with oxidative stress and pro-inflammatory changes which together provoke ED.
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